Messoud Ashina Selected Research

Adenylyl Cyclases (Adenylyl Cyclase)

1/2022	PACAP38- and VIP-induced cluster headache attacks are not associated with changes of plasma CGRP or markers of mast cell activation.
1/2022	Effect of KATP channel blocker glibenclamide on PACAP38-induced headache and hemodynamic.
1/2021	Infusion of Pituitary Adenylate Cyclase-Activating Polypeptide-38 in Patients with Rosacea Induces Flushing and Facial Edema that Can Be Attenuated by Sumatriptan.
1/2021	Effect of Vasoactive Intestinal Polypeptide on Development of Migraine Headaches: A Randomized Clinical Trial.
11/2020	The effect of pituitary adenylate cyclase-activating peptide-38 and vasoactive intestinal peptide in cluster headache.
10/2020	Two-hour infusion of vasoactive intestinal polypeptide induces delayed headache and extracranial vasodilation in healthy volunteers.
2/2020	Investigation of sumatriptan and ketorolac trometamol in the human experimental model of headache.
1/2019	Effect of the H1-antihistamine clemastine on PACAP38 induced migraine.
1/2019	Calcitonin-gene related peptide and disease activity in cluster headache.
1/2018	Cranial parasympathetic activation induces autonomic symptoms but no cluster headache attacks.

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Messoud Ashina Research Topics

Disease

153	Migraine Disorders (Migraine) 06/2022 - 10/2005
84	Headache (Headaches) 06/2022 - 04/2002
26	Pain (Aches) 04/2022 - 04/2002
22	Migraine without Aura (Common Migraine) 01/2022 - 01/2009
21	Epilepsy (Aura) 01/2022 - 09/2008
12	Migraine with Aura (Familial Hemiplegic Migraine) 01/2022 - 09/2008
10	Cluster Headache (Cluster Headaches) 01/2022 - 05/2017
7	Hypoxia (Hypoxemia) 01/2022 - 12/2014
6	Nausea 07/2021 - 12/2010
5	Hypersensitivity (Allergy) 01/2021 - 09/2008
5	Tension-Type Headache (Tension Headache) 01/2021 - 04/2002
4	Headache Disorders (Headache Syndromes) 10/2022 - 04/2002
4	Post-Traumatic Headache 01/2021 - 06/2020
3	Ganglion Cysts (Ganglion) 01/2022 - 09/2018
3	Acute Pain 08/2021 - 06/2005
3	Photophobia (Light Sensitivity) 07/2021 - 12/2010
3	Hyperacusis (Phonophobia) 07/2021 - 12/2010
3	Vomiting 07/2021 - 12/2010
3	Flushing 01/2021 - 01/2021
3	Fatigue 01/2021 - 11/2014
3	Brain Concussion (Cerebral Concussion) 12/2020 - 06/2020
3	Inflammation (Inflammations) 10/2019 - 11/2011
3	Neurogenic Inflammation 06/2013 - 01/2010
2	Nervous System Diseases (Neurological Disorders) 01/2022 - 01/2019
2	Stroke (Strokes) 01/2021 - 01/2021
2	Dizziness (Lightheadedness) 01/2021 - 01/2011
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 01/2017
2	Respiratory Tract Infections (Respiratory Tract Infection) 01/2020 - 11/2014
2	Prescription Drug Overuse 01/2019 - 09/2018
2	Heart Failure 01/2019 - 06/2014

Drug/Important Bio-Agent (IBA)

59	Calcitonin Gene-Related PeptideIBA 06/2022 - 10/2005
30	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 01/2022 - 01/2009
25	Pharmaceutical PreparationsIBA 10/2022 - 04/2002
25	Monoclonal AntibodiesIBA 06/2022 - 04/2016
24	erenumabIBA 06/2022 - 04/2016
21	Adenylyl Cyclases (Adenylyl Cyclase)IBA 01/2022 - 06/2010
15	Peptides (Polypeptides)IBA 01/2022 - 01/2010
13	Biomarkers (Surrogate Marker)IBA 12/2021 - 10/2005
13	Sumatriptan (Imigran)FDA LinkGeneric 01/2021 - 04/2011
11	KATP ChannelsIBA 01/2022 - 08/2017
11	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))IBA 01/2022 - 10/2013
11	Calcitonin Gene-Related Peptide Receptors (Calcitonin-Gene Related Peptide Receptor)IBA 01/2021 - 01/2010
10	Serotonin (5 Hydroxytryptamine)IBA 01/2019 - 01/2003
9	Calcitonin Gene-Related Peptide Receptor AntagonistsIBA 01/2022 - 12/2010
9	Tryptamines (Triptans)IBA 07/2021 - 04/2009
9	NeuropeptidesIBA 01/2021 - 09/2008
8	eptinezumabIBA 06/2022 - 11/2014
8	ProstaglandinsIBA 12/2017 - 01/2003
8	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2017 - 04/2002
7	fremanezumabIBA 06/2022 - 01/2019
7	Glutamic Acid (Glutamate)FDA Link 01/2021 - 06/2005
6	galcanezumabIBA 06/2022 - 12/2017
6	Adenosine (Adenocard)FDA LinkGeneric 04/2022 - 01/2003
6	Cromakalim (Levcromakalim)IBA 01/2021 - 01/2019
6	salicylhydroxamic acid (SHAM)IBA 01/2020 - 03/2016
6	Nitroglycerin (Dynamite)FDA LinkGeneric 01/2020 - 02/2010
6	Cilostazol (Pletal)FDA LinkGeneric 10/2019 - 11/2014
5	Histamine (Histamine Dihydrochloride)FDA Link 01/2022 - 01/2003
5	Sildenafil Citrate (Viagra)FDA Link 01/2021 - 06/2018
5	Vasodilator Agents (Vasodilators)IBA 01/2021 - 01/2011
5	Guanosine Monophosphate (5' Guanylic Acid)IBA 12/2020 - 06/2010
5	Neurotransmitter Agents (Neurotransmitter)IBA 12/2017 - 01/2009
4	Type A Botulinum Toxins (Botox)FDA Link 01/2022 - 06/2011
4	Glyburide (Glibenclamide)FDA LinkGeneric 01/2022 - 01/2020
4	Carbon MonoxideIBA 01/2022 - 12/2014
4	PotassiumIBA 10/2021 - 10/2019
4	Type I Pituitary Adenylate Cyclase-Activating Polypeptide ReceptorsIBA 01/2021 - 03/2014
4	Protein Isoforms (Isoforms)IBA 01/2021 - 11/2019
4	Adenosine Triphosphate (ATP)IBA 01/2021 - 01/2003
4	Adenosine Monophosphate (AMP)IBA 12/2020 - 06/2010
4	Nitric Oxide Synthase (NO Synthase)IBA 01/2017 - 04/2002
3	CalciumIBA 10/2021 - 01/2020
3	lasmiditanIBA 01/2021 - 04/2019
3	Protons (Proton)IBA 01/2021 - 01/2020
3	telcagepantIBA 01/2020 - 12/2010
3	AntibodiesIBA 01/2019 - 11/2017
3	Analgesics (Analgesic Drugs)IBA 01/2019 - 04/2002
3	Natriuretic PeptidesIBA 01/2019 - 06/2014
3	Prostaglandins EIBA 08/2012 - 01/2003
3	Epoprostenol (Prostacyclin)FDA LinkGeneric 11/2011 - 09/2008
2	Caffeine (No Doz)FDA LinkGeneric 04/2022 - 01/2022
2	Purinergic P1 Receptors (Adenosine Receptor)IBA 04/2022 - 01/2022
2	Purinergic P1 Receptor AntagonistsIBA 04/2022 - 01/2022
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2022 - 03/2016
2	Tryptases (Tryptase)IBA 01/2022 - 01/2019
2	Hormones (Hormone)IBA 01/2022 - 04/2021
2	BMS204352IBA 10/2021 - 10/2020
2	CreatineIBA 01/2021 - 01/2021
2	KynurenineIBA 01/2021 - 07/2011
2	Endothelin-1 (Endothelin 1)IBA 01/2020 - 03/2018
2	Biological ProductsIBA 01/2020 - 01/2018
2	gamma-Aminobutyric Acid (GABA)IBA 01/2020 - 01/2017
2	Vasoconstrictor AgentsIBA 01/2020 - 03/2018
2	5-HT1B Serotonin ReceptorIBA 01/2019 - 01/2018
2	SB 207145IBA 01/2019 - 01/2018
2	5- methyl- 8- (4- methyl- piperazin- 1- yl)- 4- oxo- 4H- chromene- 2- carboxylic acid (4-morpholin-4-yl-phenyl)amideIBA 01/2019 - 01/2018

Therapy/Procedure

23	Therapeutics 01/2022 - 01/2010
17	Intravenous Infusions 01/2022 - 10/2010
3	Punctures 10/2020 - 01/2017
2	Intravenous Administration 10/2019 - 06/2013